This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010]
Overall distribution
Tissue specific distribution
Expression restricted in 2 cancer type(s)
Cancer specific in breast cancer subtype (Basal; TNBC)
Overall distribution
Tissue specific distribution
Gscore (Amp):
0.86 (Driver)
Gscore (Del):
0.00
Recurrently amplified in 3 cancer type(s)
Overall distribution
Tissue specific distribution
Mscore:
0.00
Overall
Tissue specific
Total fusion occurrence:
NA
Overall
Tissue specific
Functional class:
Epigenetic
JensenLab PubMed score:
24.34 (Percentile rank: 50.65%)
PubTator score:
38.70 (Percentile rank: 63.72%)
Target development/druggability level:
TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
