The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
Overall distribution
Tissue specific distribution
Overall distribution
Tissue specific distribution
Gscore (Amp):
3.05 (Driver)
Gscore (Del):
0.00
Recurrently amplified in 7 cancer type(s)
Overall distribution
Tissue specific distribution
Mscore:
2.15 (Driver)
Recurrently mutated in 4 cancer type(s)
Overall
Tissue specific
Total fusion occurrence:
16 (Driver)
Fusions detected in 6 cancer type(s)
Overall
Tissue specific
STRONGLY SELECTIVE
Functional class:
Kinase (protein kinase)
JensenLab PubMed score:
10013.12 (Percentile rank: 99.72%)
PubTator score:
20799.95 (Percentile rank: 99.96%)
Target development/druggability level:
TclinThese targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
Tractability (small molecule):
Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
Tractability (antibody):
Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
