Mutation

 

The putative cancer-causing GESPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Pan-cancer level overall M-score of GESPs


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 HGNC Name  Ensembl Gene ID  HGNC Symbol  Genomic Location  Overall_Mscore  No. of Cancer Types 
anoctamin 6ENSG00000177119ANO6chr12:45215987-45440404:+  0.04    1  
leukocyte associated immunoglobulin like receptor 1ENSG00000167613LAIR1chr19:54351384-54370558:-  0.04    1  
protein tyrosine phosphatase receptor type FENSG00000142949PTPRFchr1:43525187-43623666:+  0.04    1  
integrin subunit beta 3ENSG00000259207ITGB3chr17:47253846-47311816:+  0.04    1  
TNF receptor superfamily member 1AENSG00000067182TNFRSF1Achr12:6328757-6342114:-  0.04    1  
immunoglobulin superfamily member 3ENSG00000143061IGSF3chr1:116574399-116667755:-  0.04    1  
LIM domain containing preferred translocation partner in lipomaENSG00000145012LPPchr3:188153284-188890671:+  0.04    1  
tumor suppressor candidate 3ENSG00000104723TUSC3chr8:15417215-15766649:+  0.03    1  
myotubularin 1ENSG00000171100MTM1chrX:150568619-150673322:+  0.03    1  
xenotropic and polytropic retrovirus receptor 1ENSG00000143324XPR1chr1:180632004-180890251:+  0.03    1  
regulator of G protein signaling 1ENSG00000090104RGS1chr1:192575727-192580031:+  0.03    1  
serine peptidase inhibitor, Kunitz type 1ENSG00000166145SPINT1chr15:40844018-40858207:+  0.03    1  
ATPase secretory pathway Ca2+ transporting 2ENSG00000064270ATP2C2chr16:84368527-84464187:+  0.03    1  
membrane metalloendopeptidaseENSG00000196549MMEchr3:155024124-155183729:+  0.03    1  
phosphoprotein membrane anchor with glycosphingolipid microdomains 1ENSG00000076641PAG1chr8:80967810-81112068:-  0.03    1  
integrin subunit beta 6ENSG00000115221ITGB6chr2:160099666-160271888:-  0.03    1  
ATP binding cassette subfamily C member 3ENSG00000108846ABCC3chr17:50634777-50692252:+  0.03    1  
protein kinase C alphaENSG00000154229PRKCAchr17:66302636-66810743:+  0.03    1  
solute carrier family 4 member 7ENSG00000033867SLC4A7chr3:27372721-27484420:-  0.03    1  
alkaline phosphatase, placentalENSG00000163283ALPPchr2:232378534-232382889:+  0.03    1  

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