Copy Number

 

The putative cancer-associated GESPs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).

 

Pan-cancer level overall G-score of GESPs that recurrently gained or lost copy number in at least one cancer types


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Overall_Gscore No. of Cancer Types
 HGNC Name  Ensembl Gene ID  HGNC Symbol  Genomic Location  Amplification  Deletion  Amplification  Deletion 
par-3 family cell polarity regulatorENSG00000148498PARD3chr10:34109560-34815325:-  0    0.37    0    2  
small ArfGAP 1ENSG00000112305SMAP1chr6:70667776-70862015:+  0    0.37    0    2  
scavenger receptor family member expressed on T cells 1ENSG00000214279SCART1chr10:133453928-133523558:+  0    0.37    0    3  
erythrocyte membrane protein band 4.1 like 2ENSG00000079819EPB41L2chr6:130839347-131063322:-  0    0.37    0    3  
chondroitin sulfate proteoglycan 5ENSG00000114646CSPG5chr3:47562239-47580792:-  0    0.36    0    2  
ATPase copper transporting betaENSG00000123191ATP7Bchr13:51932673-52011494:-  0    0.36    0    2  
actinin alpha 1ENSG00000072110ACTN1chr14:68874143-68979440:-  0    0.36    0    2  
CD101 moleculeENSG00000134256CD101chr1:117001750-117036476:+  0    0.35    0    2  
macrophage stimulating 1 receptorENSG00000164078MST1Rchr3:49887002-49903873:-  0    0.35    0    2  
G protein-coupled receptor 107ENSG00000148358GPR107chr9:130053426-130140169:+  0    0.34    0    2  
interleukin 17 receptor DENSG00000144730IL17RDchr3:57089982-57170306:-  0    0.34    0    2  
solute carrier family 22 member 3ENSG00000146477SLC22A3chr6:160348268-160452581:+  0    0.34    0    2  
EPH receptor B2ENSG00000133216EPHB2chr1:22710839-22921500:+  0    0.34    0    2  
C-X-C motif chemokine receptor 5ENSG00000160683CXCR5chr11:118883766-118897799:+  0    0.33    0    2  
TNF receptor superfamily member 11aENSG00000141655TNFRSF11Achr18:62325287-62391292:+  0    0.33    0    3  
family with sequence similarity 171 member A2ENSG00000161682FAM171A2chr17:44353215-44363875:-  0    0.33    0    2  
chloride intracellular channel 4ENSG00000169504CLIC4chr1:24745357-24844324:+  0    0.33    0    2  
melanocortin 1 receptorENSG00000258839MC1Rchr16:89912119-89920977:+  0    0.33    0    3  
solute carrier family 1 member 5ENSG00000105281SLC1A5chr19:46774883-46788594:-  0    0.33    0    1  
glutamate ionotropic receptor NMDA type subunit 2DENSG00000105464GRIN2Dchr19:48394875-48444931:+  0    0.32    0    1  

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