Copy Number
The putative cancer-associated GESPs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 22 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||||
| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | Amplification | Deletion | Amplification | Deletion |
| angiopoietin 1 | ENSG00000154188 | ANGPT1 | chr8:107249482-107498055:- | 0.14 | 0 | 1 | 0 |
| cyclin dependent kinase 16 | ENSG00000102225 | CDK16 | chrX:47217860-47229997:+ | 0.14 | 0 | 1 | 0 |
| desmoplakin | ENSG00000096696 | DSP | chr6:7541575-7586717:+ | 0.14 | 0 | 1 | 0 |
| frizzled class receptor 6 | ENSG00000164930 | FZD6 | chr8:103298433-103332866:+ | 0.14 | 0 | 1 | 0 |
| oxoglutarate receptor 1 | ENSG00000165621 | OXGR1 | chr13:96985719-96994730:- | 0.14 | 0 | 1 | 0 |
| V-set and transmembrane domain containing 5 | ENSG00000214376 | VSTM5 | chr11:93818232-93850531:- | 0.14 | 0 | 1 | 0 |
| calreticulin | ENSG00000179218 | CALR | chr19:12938578-12944489:+ | 0.14 | 0 | 1 | 0 |
| family with sequence similarity 126 member A | ENSG00000122591 | FAM126A | chr7:22889371-23014130:- | 0.14 | 0 | 1 | 0 |
| potassium voltage-gated channel subfamily Q member 4 | ENSG00000117013 | KCNQ4 | chr1:40784012-40840452:+ | 0.14 | 0 | 1 | 0 |
| ADP ribosylation factor 1 | ENSG00000143761 | ARF1 | chr1:228082660-228099212:+ | 0.14 | 0.22 | 1 | 1 |
| solute carrier family 36 member 4 | ENSG00000180773 | SLC36A4 | chr11:93144171-93197964:- | 0.14 | 0 | 1 | 0 |
| claudin 10 | ENSG00000134873 | CLDN10 | chr13:95433604-95579759:+ | 0.13 | 0 | 1 | 0 |
| microtubule actin crosslinking factor 1 | ENSG00000127603 | MACF1 | chr1:39081316-39487177:+ | 0.13 | 0 | 1 | 0 |
| ATPase phospholipid transporting 11C | ENSG00000101974 | ATP11C | chrX:139726346-139945276:- | 0.13 | 0 | 1 | 0 |
| claudin 12 | ENSG00000157224 | CLDN12 | chr7:90383721-90513402:+ | 0.13 | 0 | 1 | 0 |
| STEAP family member 1 | ENSG00000164647 | STEAP1 | chr7:90154375-90164829:+ | 0.13 | 0 | 1 | 0 |
| protein tyrosine kinase 6 | ENSG00000101213 | PTK6 | chr20:63528001-63537370:- | 0.13 | 0 | 1 | 0 |
| membrane palmitoylated protein 1 | ENSG00000130830 | MPP1 | chrX:154778684-154821007:- | 0.13 | 0 | 1 | 0 |
| cell adhesion associated, oncogene regulated | ENSG00000064309 | CDON | chr11:125955796-126063335:- | 0.13 | 0.6 | 1 | 3 |
| solute carrier family 9 member A6 | ENSG00000198689 | SLC9A6 | chrX:135985424-136047269:+ | 0.13 | 0 | 1 | 0 |
|
Showing page 22 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.