TCEA Mutation

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Mutation

The putative cancer-causing HAMPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

Summary of mutation frequency of the HAMPs in each cancer type

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Symbol	Gene ID	ACC_Mut%	BLCA_Mut%	BRCA_Mut%	CESC_Mut%	CHOL_Mut%	COAD_Mut%	DLBC_Mut%	ESCA_Mut%	GBM_Mut%	HNSC_Mut%	KICH_Mut%	KIRC_Mut%	KIRP_Mut%	LAML_Mut%	LGG_Mut%	LIHC_Mut%	LUAD_Mut%	LUSC_Mut%	MESO_Mut%	OV_Mut%	PAAD_Mut%	PCPG_Mut%	PRAD_Mut%	READ_Mut%	SARC_Mut%	SKCM_Mut%	STAD_Mut%	TGCT_Mut%	THCA_Mut%	THYM_Mut%	UCEC_Mut%	UCS_Mut%	UVM_Mut%
HDAC10	ENSG00000100429	0	0.73	0.2	0.35	0	0.99	0	0	0	0.79	0	0.27	0.36	0	0.39	0	0.53	1.03	0	0	0	0	0.2	0.67	0	0.86	1.14	0.69	0	0	3.77	1.75	0
HDAC6	ENSG00000094631	2.17	1.95	1.27	2.42	0	2.71	0	1.63	0.76	1.18	0	0.54	0.71	0	0.59	0.83	2.29	1.86	0	1.21	0.56	0	0.4	1.33	0.85	1.07	2.05	0	0	0	10.94	3.51	0
HDAC7	ENSG00000061273	1.09	0.49	0.1	1.38	0	2.22	0	0	0.25	1.18	1.52	0.27	0.71	0	0.2	0.28	0.71	0.82	0	0.49	0.56	0	0.2	1.33	0.85	1.93	3.42	0	0	0	3.96	3.51	0
HDAC4	ENSG00000068024	1.09	0.73	0.69	1.04	0	4.43	0	3.26	1.02	1.78	0	0.27	0	0.71	0.78	1.65	3.17	3.09	0	0.97	0.56	0	0.2	0	0	2.79	5.69	0	0	0	9.62	0	0
HDAC5	ENSG00000108840	0	1.22	0.59	2.08	0	3.2	0	1.09	1.02	0.39	1.52	0	1.07	0	0.2	0.83	0.53	0.62	0	0	1.13	0	0.8	0.67	0.42	2.15	2.51	0	0	0	5.85	0	2.5
HDAC9	ENSG00000048052	1.09	1.7	0.49	1.73	2.78	5.91	2.7	4.35	1.27	3.16	1.52	0.81	0.36	0	0.2	2.48	8.11	5.98	0	0.73	1.69	0	0.4	5.33	0.42	12.88	2.73	0	0	0	6.23	0	0
SIRT6	ENSG00000077463	0	0.49	0.29	0.35	0	1.23	0	0.54	0	0	0	0.54	0	0.71	0	0	0.35	0.82	0	0	0	0	0	0	0	0.43	0.46	0	0	0	0.94	0	0
SIRT3	ENSG00000142082	0	0.49	0.2	0.35	0	0.99	0	0.54	0.51	0.39	1.52	0	0	0	0.39	0.28	0.35	0.41	0	0.24	0	0	0.2	0	0.85	0.43	0	0	0	0	2.26	0	0
SIRT1	ENSG00000096717	1.09	2.19	0.39	0.69	0	1.97	0	0.54	0.25	0.39	0	0.81	0	0.71	0.2	0.28	0.35	0.41	0	0.24	0.56	0	0.6	2	0.42	0.64	1.82	0	0	0	4.91	1.75	0
SIRT2	ENSG00000068903	0	0.49	0.29	0.69	0	0.25	0	0	0.51	0.2	0	0	0	0.71	0	0.55	0.35	1.44	0	0.24	0	0	0.2	0.67	0.42	0.43	0.68	0	0	0	2.26	1.75	0
SIRT7	ENSG00000187531	0	0.97	0.29	0.69	0	0.99	0	0.54	0.51	0.2	0	0.81	0.71	0	0.2	0	0.71	0.62	0	0	0	0	0	0	0.42	0.64	0.91	0	0	0	1.89	0	0
SIRT4	ENSG00000089163	0	0.24	0.1	0.35	0	1.48	2.7	0	0.51	0.39	0	0.27	0	0	0.2	0.28	0.53	0.62	0	0.24	0	0	0.2	0.67	0	0.86	0.46	0	0.2	0	3.02	0	0
SIRT5	ENSG00000124523	0	0.73	0.1	1.04	0	0.99	0	0	0.25	0.39	0	0	0	0	0.39	0	0.18	0.21	0	0.24	0	0	0	0.67	0	1.29	0.91	0.69	0	0	3.77	0	0

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