Mutation

 

The putative cancer-causing HAMPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Summary of mutation frequency of the HAMPs in each cancer type


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 Symbol  Gene ID  ACC_Mut%  BLCA_Mut%  BRCA_Mut%  CESC_Mut%  CHOL_Mut%  COAD_Mut%  DLBC_Mut%  ESCA_Mut%  GBM_Mut%  HNSC_Mut%  KICH_Mut%  KIRC_Mut%  KIRP_Mut%  LAML_Mut%  LGG_Mut%  LIHC_Mut%  LUAD_Mut%  LUSC_Mut%  MESO_Mut%  OV_Mut%  PAAD_Mut%  PCPG_Mut%  PRAD_Mut%  READ_Mut%  SARC_Mut%  SKCM_Mut%  STAD_Mut%  TGCT_Mut%  THCA_Mut%  THYM_Mut%  UCEC_Mut%  UCS_Mut%  UVM_Mut% 
SP100  ENSG00000067066    0    2.43    0.98    2.77    0    1.72    0    0    1.78    0.79    0    0.27    0    1.42    0.59    0    3.35    1.86    1.22    1.46    0.56    0    0.4    1.33    0    3    4.1    0.69    0    0    7.74    0    0  
SP110  ENSG00000135899    0    0.97    0.49    0.35    0    0.99    0    0    1.27    0.2    0    0    0    0    0.2    0.55    1.76    0.62    0    0.49    0    0    0.6    2    0.42    1.72    2.05    0    0    0    5.66    0    0  
TRIM28  ENSG00000130726    0    1.22    0.59    1.38    0    0.74    0    0    0.76    0.39    0    0.54    0.71    0    0.39    1.38    1.06    0.82    1.22    0    0    0    0.6    1.33    0.42    1.5    2.05    0.69    0.2    0    5.09    0    0  
TRIM33  ENSG00000197323    1.09    1.46    0.59    0.69    0    3.2    0    1.09    0.51    0.59    0    0.54    1.07    0.71    0.2    0    1.41    0.82    0    0.73    1.13    0    0.6    2    0    0.64    2.73    0    0.2    0    7.36    1.75    0  
TRIM24  ENSG00000122779    0    2.92    0.98    1.04    0    3.94    2.7    1.09    1.02    0.99    0    0.81    0    0    0.2    0.28    1.59    1.86    0    0.49    0.56    0    0    4    0    3.22    1.82    0    0.2    0    5.09    0    0  
TRIM66  ENSG00000166436    0    0    0.29    1.38    0    4.43    0    1.09    0    0    0    0    0.36    0    0    2.2    0    0    1.22    0    0    0    0    1.33    0    0    0    0    0    0    6.98    0    0  
BAZ1A  ENSG00000198604    1.09    2.68    1.08    2.08    0    3.94    0    0    1.02    0.99    0    0.27    0    0    0.2    0.55    1.76    3.3    0    0.97    0    0    0.6    2    0.42    3    3.42    0    0    0    8.11    0    0  
SMARCA2  ENSG00000080503    1.09    5.6    1.27    2.08    0    4.93    2.7    1.63    1.78    2.37    0    1.08    0.36    0.71    0.2    1.65    3.7    2.27    0    1.46    0.56    0    0.6    2.67    0.85    4.29    6.15    0    0    0    9.81    1.75    0  
SMARCA4  ENSG00000127616    1.09    5.6    1.47    2.77    0    5.91    2.7    7.07    1.78    4.34    0    2.98    4.27    0.71    4.88    3.03    7.94    3.51    1.22    0.97    1.13    0    0.4    3.33    0.42    7.3    5.69    0    0.41    1.63    9.81    3.51    1.25  
ASH1L  ENSG00000116539    1.09    7.3    2.65    3.46    2.78    9.11    0    1.09    1.27    2.37    0    0.81    1.42    0.71    0.39    1.93    6.17    5.36    1.22    1.21    1.13    0.56    1.21    6    0.85    9.44    8.2    0    0.41    0.81    13.58    0    0  
BAZ1B  ENSG00000009954    0    2.92    1.18    2.77    0    3.2    0    0.54    1.02    0.79    0    0.54    1.07    0    0.39    0.55    2.47    2.27    0    0.73    0.56    0    0.6    4    0.42    3.65    2.51    0.69    0    0    6.98    1.75    0  
PBRM1  ENSG00000163939    1.09    4.62    1.08    2.08    19.44    5.42    2.7    2.17    0.76    2.17    1.52    40.11    3.91    2.13    0.98    1.93    1.59    2.27    2.44    0.49    2.82    0    0.4    2    1.69    4.72    5.92    0.69    0    1.63    9.81    3.51    0  
ZMYND8  ENSG00000101040    1.09    4.14    1.08    1.38    0    5.42    0    0    1.02    0.99    0    0.81    0.36    0    0    0    2.47    1.65    1.22    0.73    1.69    0.56    0.4    2.67    0.42    4.08    3.87    0.69    0    0    9.25    1.75    0  
ZMYND11  ENSG00000015171    0    0.49    0.29    0.35    0    2.46    0    0    0.76    1.18    0    0.27    0.36    0    0    0.28    1.41    0.21    0    0.24    0.56    0    0.2    0.67    0.42    0.21    2.28    0    0.2    0    3.77    0    0  
BRD4  ENSG00000141867    0    2.92    0.59    3.11    0    4.93    2.7    2.72    2.04    1.58    0    0.27    0.71    0.71    0    1.65    1.06    2.06    0    0.73    1.13    0    0.2    2    0.85    5.79    3.42    0    0    1.63    7.36    0    0  
BPTF  ENSG00000171634    0    6.33    1.27    3.81    0    4.68    2.7    2.17    1.53    1.38    1.52    1.08    1.78    0    0.39    2.48    4.23    3.92    0    1.7    2.26    0.56    0.6    2.67    0.42    7.94    5.69    0.69    1.02    0    8.68    0    0  
BRD2  ENSG00000204256    0    4.38    0.2    1.73    2.78    2.96    2.7    1.09    1.02    0.2    0    0.54    1.42    0    0.78    0.28    1.23    1.03    0    1.21    0.56    0    0.2    1.33    0.85    2.58    3.19    0    0    0.81    4.53    0    0  
BRDT  ENSG00000137948    1.09    2.43    0.59    1.38    2.78    1.72    0    0.54    0.76    1.38    0    0.54    0    0    0.2    0.83    3.17    2.68    0    0.73    0.56    0    0    3.33    0    6.22    2.28    0    0.41    0    8.11    1.75    0  
BRD3  ENSG00000169925    2.17    0    0.29    0.35    0    3.2    2.7    1.09    0.76    0.39    0    0.27    0.36    0    0.78    0.28    0.71    0.41    0    0.49    0.56    0    0.2    1.33    0.85    1.29    3.87    0    0.2    0    6.23    1.75    0  
KMT2A  ENSG00000118058    4.35    10.95    2.16    3.46    2.78    7.64    5.41    4.35    1.53    4.54    0    1.36    1.78    1.42    0.78    3.03    5.64    5.15    1.22    3.88    2.26    0    1.21    1.33    1.69    11.16    9.57    0    1.22    0    13.58    0    0  

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