PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
catenin beta 1ENSG00000168036CTNNB1chr3:41194837-41260096:+Tchem5488.79
Jun proto-oncogene, AP-1 transcription factor subunitENSG00000177606JUNchr1:58780788-58784327:-Tchem3644.48
CD19 moleculeENSG00000177455CD19chr16:28931939-28939346:+Tclin2076.83
glyceraldehyde-3-phosphate dehydrogenaseENSG00000111640GAPDHchr12:6533927-6538374:+Tchem2345.81
lysine acetyltransferase 6BENSG00000156650KAT6Bchr10:74825582-75032622:+Tbio73.0524
fibroblast growth factor receptor 4ENSG00000160867FGFR4chr5:177086886-177098144:+Tclin266.125
insulin like growth factor binding protein 3ENSG00000146674IGFBP3chr7:45912245-45921874:-Tchem2165.75
insulin like growth factor 2ENSG00000167244IGF2chr11:2129112-2149603:-Tbio2551.68
carbonic anhydrase 2ENSG00000104267CA2chr8:85463852-85481493:+Tclin3644.41
eukaryotic translation elongation factor 2ENSG00000167658EEF2chr19:3976056-3985469:-Tbio322.791
ribonucleotide reductase catalytic subunit M1ENSG00000167325RRM1chr11:4094707-4138876:+Tclin1416.52
CD79b moleculeENSG00000007312CD79Bchr17:63928740-63932354:-Tbio181.363
mitogen-activated protein kinase 1ENSG00000100030MAPK1chr22:21754500-21867680:-Tchem5685.03
interferon gammaENSG00000111537IFNGchr12:68154768-68159747:-Tbio15643.2
superoxide dismutase 2ENSG00000112096SOD2chr6:159669057-159762529:-Tbio2137.58
integrin subunit beta 3ENSG00000259207ITGB3chr17:47253846-47311816:+Tclin1124.73
cyclin D2ENSG00000118971CCND2chr12:4273772-4305350:+Tbio287.385
androgen receptorENSG00000169083ARchrX:67544032-67730619:+Tclin7221.94
cellular communication network factor 3ENSG00000136999NOVchr8:119416306-119424353:+Tbio386.486
ret proto-oncogeneENSG00000165731RETchr10:43077027-43130351:+Tclin3384.44

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